- Title
- Non-contrast based approach for liver function quantification using Bayesian-based intravoxel incoherent motion diffusion weighted imaging: A pilot study
- Creator
- Phonlakrai, Monchai; Ramadan, Saadallah; Greer, Peter; Simpson, John; Skehan, Kate; Goodwin, Jonathan; Trada, Yuvnik; Martin, Jarad; Sridharan, Swetha; Gan, Lay Theng; Siddique, Sabbir Hossain
- Relation
- Journal of Applied Clinical Medical Physics Vol. 24, Issue 11, no. e14178
- Publisher Link
- http://dx.doi.org/10.1002/acm2.14178
- Publisher
- John Wiley & Sons
- Resource Type
- journal article
- Date
- 2023
- Description
- Purpose: Liver cirrhosis disrupts liver function and tissue perfusion, detectable by magnetic resonance imaging (MRI). Assessing liver function at the voxel level with 13-b value intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) could aid in radiation therapy liver-sparing treatment for patients with early impairment. This study aimed to evaluate the feasibility of IVIM-DWI for liver function assessment and correlate it with other multiparametric (mp) MRI methods at the voxel level. Method: This study investigates the variability of apparent diffusion coefficient (ADC) derived from 13-b value IVIM-DWI and B1-corrected dual flip angle (DFA) T1 mapping. Experiments were conducted in-vitro with QIBA and NIST phantoms and in 10 healthy volunteers for IVIM-DWI. Additionally, 12 patients underwent an mp-MRI examination. The imaging protocol included a 13-b value IVIM-DWI sequence for generating IVIM parametric maps. B1-corrected DFA T1 pulse sequence was used for generating T1 maps, and Gadoxatate low temporal resolution dynamic contrast-enhanced (LTR-DCE) MRI was used for generating the Hepatic extraction fraction (HEF) map. The Mann-Whitney U test was employed to compare IVIM-DWI parameters (Pure Diffusion, Dslow; Pseudo diffusion, Dfast; and Perfusion Fraction, Fp) between the healthy volunteer and patient groups. Furthermore, in the patient group, statistical correlations were assessed at a voxel level between LTR-DCE MRI-derived HEF, T1 post-Gadoxetate administration, ΔT1%, and various IVIM parameters using Pearson correlation. Results: For-vitro measurements, the maximum coefficient of variation of the ADC and T1 parameters was 12.4% and 16.1%, respectively. The results also showed that Fp and Dfast were able to distinguish between healthy liver function and mild liver function impairment at the global level, with p = 0.002 for Fp and p < 0.001 for Dfast. Within the patient group, these parameters also exhibited a moderate correlation with HEF at the voxel level. Conclusion: Overall, the study highlighted the potential of Dfast and Fp for detecting liver function impairment at both global and pixel levels.
- Subject
- DCE-MRI; HCC; intravoxel incoherent motion diffusion; liver cirrhosis; liver function; T1 mapping
- Identifier
- http://hdl.handle.net/1959.13/1493051
- Identifier
- uon:53472
- Identifier
- ISSN:1526-9914
- Rights
- x
- Language
- eng
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